Antigenic determinant - definition of antigenic determinant by The Free Dictionary https: Related to antigenic determinant: Also called antigenic determinant. Switch to new thesaurus. References in periodicals archive? Analysis of the antigenic determinant groups of the mannan of Candida albicans serotype A. Immunochemistry of pathogenic yeast, Candida species, focusing on mannan. The proportion of epitopes that are conformational is unknown. By contrast, linear epitopes interact with the paratope based on their primary structure.
A linear epitope is formed by a continuous sequence of amino acids from the antigen. T cell epitopes are presented on the surface of an antigen-presenting cell , where they are bound to MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length, whereas MHC class II molecules present longer peptides, amino acids in length,  and non-classical MHC molecules also present non-peptidic epitopes such as glycolipids.
Epitopes are sometimes cross-reactive. This property is exploited by the immune system in regulation by anti-idiotypic antibodies originally proposed by Nobel laureate Niels Kaj Jerne.
If an antibody binds to an antigen's epitope, the paratope could become the epitope for another antibody that will then bind to it.
If this second antibody is of IgM class, its binding can upregulate the immune response; if the second antibody is of IgG class, its binding can downregulate the immune response. Another technique involves high-throughput mutagenesis , an epitope mapping strategy developed to improve rapid mapping of conformational epitopes on structurally complex proteins.
MHC class I and II epitopes can be reliably predicted by computational means alone,  although not all in-silico T cell epitope prediction algorithms are equivalent in their accuracy. Epitopes are often used in proteomics and the study of other gene products.
Overexpression and purification of C-terminal fragment of the passenger domain of Hap protein from nontypeable Haemophilus influenzae in a highly optimized Escherichia coli expression system.
Antibodies with specific recognition for specific antigenic determinants could now be prepared. The past as prologue: The L segment encodes the RNA-dependent RNA polymerase; antigenic determinants are the M-encoded viral surface glycoproteins Gn and Gc, which are responsible for viral attachment, cell fusion, hemagglutination, and the induction of neutralizing antibodies, and the S-encoded nucleocapsid protein N, which plays a role in complement fixation 6.
Schmallenberg virus as possible ancestor of shamonda virus. The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants unique to either allelic protein product. ELISA for determination of the haptoglobin phenotype. Antibody responses to antigenic determinants of influenza virus hemagglutinin. The wages of original antigenic sin.
determinant antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with.
antigenic determinant n (Biochemistry) the specific part of an antigen molecule to which an antibody becomes attached ep•i•tope (ˈɛp ɪˌtoʊp) n. a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant. [–75; epi- + -tope.
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. Biology, Eighth Edition (Raven) Chapter The Immune System Antigenic Determinants (Epitopes) What is the advantage of having more than one antibody attack the same structure? Antibodies recognize specific areas of antigens called epitopes. Several different antibodies can attack antigens in different areas. have one antigenic.
Start studying 3. Antigens & Antigenic Determinants. Learn vocabulary, terms, and more with flashcards, games, and other study tools. As all the surface SGPs act as blood group antigenic determinants and receptor sites for viruses, bacteria and parasites, the presence of higher number of SGPs within the membrane of goat, buffalo and pig erythrocyte indicates the higher immunological response of the animals as compared to human.